Drug interactions
Ozanimod + Regorafenib
Severity: Moderate
Ozanimod and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib and its metabolites may inhibit BCRP, which could increase exposure to active metabolites of ozanimod. This could heighten ozanimod effects such as bradycardia, hypertension and liver enzyme elevation. Clinical data on this specific pair are lacking.
What this interaction means in plain words
Ozanimod and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Regorafenib belongs to Oncology.
Why it happens
Possible BCRP inhibition by regorafenib increases exposure to ozanimod active metabolites.
What to do
Monitor heart rate, blood pressure and liver tests when combining them. Consider an alternative if ozanimod adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ozanimod and Regorafenib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Regorafenib
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Regorafenib?
MediHelp rates the interaction as moderate. Ozanimod and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib and its metabolites may inhibit BCRP, which could increase exposure to active metabolites of ozanimod. This could heighten ozanimod effects such as bradycardia, hypertension and liver enzyme elevation. Clinical data on this specific pair are lacking.
How serious is the interaction between Ozanimod and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and liver tests when combining them. Consider an alternative if ozanimod adverse effects appear.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
