Drug interactions
Ozanimod + Rifampicin
Severity: Major
Ozanimod and Rifampicin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin decreases exposure to ozanimod's active metabolites, potentially reducing efficacy in multiple sclerosis or ulcerative colitis.
What this interaction means in plain words
Ozanimod and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ozanimod belongs to Central Nervous System; Rifampicin belongs to Anti Bacterial.
Why it happens
Rifampicin induces CYP2C8 and other enzymes, accelerating formation and clearance of active metabolites.
What to do
Avoid coadministration of ozanimod with rifampicin. Use an alternative antimicrobial if possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Ozanimod with Rifampicin?
MediHelp rates the interaction as major. Ozanimod and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin decreases exposure to ozanimod's active metabolites, potentially reducing efficacy in multiple sclerosis or ulcerative colitis.
How serious is the interaction between Ozanimod and Rifampicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration of ozanimod with rifampicin. Use an alternative antimicrobial if possible.
What other medicines interact with Ozanimod?
MediHelp also lists interactions of Ozanimod with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Ozanimod page.
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