Drug interactions
Ozanimod + Secobarbital
Severity: Moderate
Ozanimod and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are enzyme inducers and may reduce exposure to ozanimod's active metabolites. Ozanimod labeling recommends against strong CYP2C8 inducers, and reduced exposure may reduce efficacy.
What this interaction means in plain words
Ozanimod and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
Enzyme induction may increase the metabolic clearance of ozanimod's active metabolites; the contribution of secobarbital to CYP2C8 induction is not well established.
What to do
Prefer a non-inducing sedative. If used together, monitor for loss of control of multiple sclerosis or ulcerative colitis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Secobarbital?
MediHelp rates the interaction as moderate. Ozanimod and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are enzyme inducers and may reduce exposure to ozanimod's active metabolites. Ozanimod labeling recommends against strong CYP2C8 inducers, and reduced exposure may reduce efficacy.
How serious is the interaction between Ozanimod and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing sedative. If used together, monitor for loss of control of multiple sclerosis or ulcerative colitis.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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