Drug interactions
Ozanimod + Sertraline
Severity: Major
Ozanimod and Sertraline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolite inhibits MAO-B in vitro, and labeling advises against use with serotonergic or noradrenergic drugs because of the potential for serotonin syndrome or hypertensive reactions. Clinical data are limited.
What this interaction means in plain words
Ozanimod and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ozanimod belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Possible MAO-B inhibition by ozanimod metabolites combined with serotonin reuptake inhibition.
What to do
Avoid the combination where possible, or monitor blood pressure and for serotonin toxicity signs. Consider an alternative antidepressant or immunomodulator.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Sertraline?
MediHelp rates the interaction as major. Ozanimod and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ozanimod's active metabolite inhibits MAO-B in vitro, and labeling advises against use with serotonergic or noradrenergic drugs because of the potential for serotonin syndrome or hypertensive reactions. Clinical data are limited.
How serious is the interaction between Ozanimod and Sertraline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor blood pressure and for serotonin toxicity signs. Consider an alternative antidepressant or immunomodulator.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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