Drug interactions
Ozanimod + Sumatriptan
Severity: Moderate
Ozanimod and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolite inhibits MAO-B, and sumatriptan is a serotonergic vasoconstrictor. Together they may raise blood pressure and, in theory, serotonergic toxicity. Sumatriptan is mainly cleared by MAO-A, so the interaction is mainly theoretical and based on the labeling for ozanimod.
What this interaction means in plain words
Ozanimod and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
In vitro MAO-B inhibition by an ozanimod metabolite may increase monoamine exposure, and triptans add serotonergic and vasoconstrictive effects.
What to do
Monitor blood pressure and heart rate when a triptan is used with ozanimod, and counsel the patient to report severe headache, agitation or palpitations. Choose a non-serotonergic acute migraine therapy if blood pressure is difficult to control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Sumatriptan?
MediHelp rates the interaction as moderate. Ozanimod and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's active metabolite inhibits MAO-B, and sumatriptan is a serotonergic vasoconstrictor. Together they may raise blood pressure and, in theory, serotonergic toxicity. Sumatriptan is mainly cleared by MAO-A, so the interaction is mainly theoretical and based on the labeling for ozanimod.
How serious is the interaction between Ozanimod and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when a triptan is used with ozanimod, and counsel the patient to report severe headache, agitation or palpitations. Choose a non-serotonergic acute migraine therapy if blood pressure is difficult to control.
What other medicines interact with Sumatriptan?
MediHelp also lists interactions of Sumatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Sumatriptan page.
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