Drug interactions
Ozanimod + Thioridazine
Severity: Major
Ozanimod and Thioridazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and conduction. With thioridazine, a strongly QT-prolonging drug, the risk of arrhythmia including torsades de pointes may increase.
What this interaction means in plain words
Ozanimod and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ozanimod belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with bradycardia increasing arrhythmia susceptibility.
What to do
Avoid starting ozanimod in patients on thioridazine unless benefit outweighs risk, and seek cardiology advice if it is necessary. Obtain a baseline ECG and monitor it afterward.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Thioridazine?
MediHelp rates the interaction as major. Ozanimod and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ozanimod can slow heart rate and conduction. With thioridazine, a strongly QT-prolonging drug, the risk of arrhythmia including torsades de pointes may increase.
How serious is the interaction between Ozanimod and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting ozanimod in patients on thioridazine unless benefit outweighs risk, and seek cardiology advice if it is necessary. Obtain a baseline ECG and monitor it afterward.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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