Drug interactions
Ozanimod + Verapamil
Severity: Moderate
Ozanimod and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolites inhibit MAO-B in vitro, so there is a theoretical risk of raised blood pressure with drugs affecting adrenergic or serotonergic pathways. Verapamil is a calcium channel blocker with no meaningful sympathomimetic action, so a hypertensive reaction is unlikely. Ozanimod can also slow heart rate and conduction, which may add to verapamil's effects on the AV node.
What this interaction means in plain words
Ozanimod and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
Additive negative chronotropic and dromotropic effects; the MAO-B inhibition concern does not apply to verapamil in any established way.
What to do
Check ECG and heart rate before starting ozanimod in patients taking verapamil, and monitor heart rate and blood pressure during initiation. Seek cardiology advice if the patient has conduction disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ozanimod and Verapamil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Verapamil?
MediHelp rates the interaction as moderate. Ozanimod and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ozanimod's active metabolites inhibit MAO-B in vitro, so there is a theoretical risk of raised blood pressure with drugs affecting adrenergic or serotonergic pathways. Verapamil is a calcium channel blocker with no meaningful sympathomimetic action, so a hypertensive reaction is unlikely. Ozanimod can also slow heart rate and conduction, which may add to verapamil's effects on the AV node.
How serious is the interaction between Ozanimod and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and heart rate before starting ozanimod in patients taking verapamil, and monitor heart rate and blood pressure during initiation. Seek cardiology advice if the patient has conduction disease.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
