Drug interactions
Ozanimod + Ziprasidone
Severity: Major
Ozanimod and Ziprasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod can slow heart rate and affect cardiac conduction, while ziprasidone prolongs the QT interval. Together they may raise the risk of arrhythmia, including torsades de pointes, especially when bradycardia is present.
What this interaction means in plain words
Ozanimod and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ozanimod belongs to Central Nervous System; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive cardiac effects: ozanimod-related bradycardia and conduction slowing combined with ziprasidone-induced QT prolongation.
What to do
Avoid starting ozanimod in patients taking ziprasidone unless a cardiologist has reviewed the case. If used together, obtain a baseline ECG and monitor heart rate, QTc and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Ziprasidone?
MediHelp rates the interaction as major. Ozanimod and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ozanimod can slow heart rate and affect cardiac conduction, while ziprasidone prolongs the QT interval. Together they may raise the risk of arrhythmia, including torsades de pointes, especially when bradycardia is present.
How serious is the interaction between Ozanimod and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting ozanimod in patients taking ziprasidone unless a cardiologist has reviewed the case. If used together, obtain a baseline ECG and monitor heart rate, QTc and electrolytes.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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