Drug interactions
Paclitaxel + Pretomanid
Severity: Minor
Paclitaxel and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid may inhibit OATP1B3, a transporter involved in hepatic uptake of paclitaxel. Exposure may be altered, but clinical data are lacking.
What this interaction means in plain words
Paclitaxel and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paclitaxel belongs to Oncology; Pretomanid belongs to Anti Bacterial.
Why it happens
Possible OATP1B3 inhibition by pretomanid reduces hepatic uptake of paclitaxel.
What to do
Monitor for paclitaxel adverse effects such as neutropenia and neuropathy if coadministered.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paclitaxel
Other interactions of Pretomanid
Frequently asked questions
Can I take Paclitaxel with Pretomanid?
MediHelp rates the interaction as minor. Paclitaxel and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid may inhibit OATP1B3, a transporter involved in hepatic uptake of paclitaxel. Exposure may be altered, but clinical data are lacking.
How serious is the interaction between Paclitaxel and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for paclitaxel adverse effects such as neutropenia and neuropathy if coadministered.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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