Drug interactions
Paclitaxel + Ranolazine
Severity: Moderate
Paclitaxel and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits P-glycoprotein, which may reduce paclitaxel efflux and raise its exposure. This could worsen neutropenia and peripheral neuropathy, though clinical data are limited.
What this interaction means in plain words
Paclitaxel and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paclitaxel belongs to Oncology; Ranolazine belongs to Cardiovascular.
Why it happens
P-glycoprotein inhibition by ranolazine may reduce paclitaxel clearance.
What to do
Monitor blood counts and neuropathy symptoms closely. Reduce the paclitaxel dose or delay cycles if significant toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Ranolazine?
MediHelp rates the interaction as moderate. Paclitaxel and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine inhibits P-glycoprotein, which may reduce paclitaxel efflux and raise its exposure. This could worsen neutropenia and peripheral neuropathy, though clinical data are limited.
How serious is the interaction between Paclitaxel and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms closely. Reduce the paclitaxel dose or delay cycles if significant toxicity occurs.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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