Drug interactions
Paclitaxel + Rucaparib
Severity: Moderate
Paclitaxel and Rucaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP3A4 and CYP2C8 in vitro and may increase paclitaxel exposure. Overlapping myelosuppression from both agents may add to the risk.
What this interaction means in plain words
Paclitaxel and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paclitaxel belongs to Oncology; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP2C8 and CYP3A4, reducing paclitaxel metabolism.
What to do
Monitor complete blood counts frequently and reduce doses if significant cytopenias or neuropathy occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Paclitaxel and Rucaparib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Paclitaxel
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Paclitaxel with Rucaparib?
MediHelp rates the interaction as moderate. Paclitaxel and Rucaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rucaparib inhibits CYP3A4 and CYP2C8 in vitro and may increase paclitaxel exposure. Overlapping myelosuppression from both agents may add to the risk.
How serious is the interaction between Paclitaxel and Rucaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and reduce doses if significant cytopenias or neuropathy occur.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
