Drug interactions
Paclitaxel + Stiripentol
Severity: Moderate
Paclitaxel and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP2C8 and has mixed CYP3A4 inhibitory and inducing effects, so paclitaxel exposure may change unpredictably, most likely increasing. Toxicity or reduced efficacy could result.
What this interaction means in plain words
Paclitaxel and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paclitaxel belongs to Oncology; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits CYP2C8 and modulates CYP3A4, altering paclitaxel metabolism.
What to do
Monitor for paclitaxel toxicity such as neutropenia and neuropathy and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Paclitaxel and Stiripentol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Paclitaxel
Other interactions of Stiripentol
Frequently asked questions
Can I take Paclitaxel with Stiripentol?
MediHelp rates the interaction as moderate. Paclitaxel and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits CYP2C8 and has mixed CYP3A4 inhibitory and inducing effects, so paclitaxel exposure may change unpredictably, most likely increasing. Toxicity or reduced efficacy could result.
How serious is the interaction between Paclitaxel and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for paclitaxel toxicity such as neutropenia and neuropathy and adjust the dose accordingly.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
