Drug interactions
Paclitaxel + Trazodone
Severity: Minor
Paclitaxel and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The legacy concern is that trazodone could alter paclitaxel exposure via P-glycoprotein, but trazodone is not an established clinically relevant P-gp inducer and no meaningful effect on paclitaxel has been demonstrated. There is no reliable evidence of a clinically significant interaction.
What this interaction means in plain words
Paclitaxel and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paclitaxel belongs to Oncology; Trazodone belongs to Central Nervous System.
Why it happens
No established mechanism; a P-glycoprotein effect is theoretical.
What to do
No dose adjustment is required. Monitor for paclitaxel toxicity and efficacy as part of routine oncology care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Trazodone?
MediHelp rates the interaction as minor. Paclitaxel and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The legacy concern is that trazodone could alter paclitaxel exposure via P-glycoprotein, but trazodone is not an established clinically relevant P-gp inducer and no meaningful effect on paclitaxel has been demonstrated. There is no reliable evidence of a clinically significant interaction.
How serious is the interaction between Paclitaxel and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor for paclitaxel toxicity and efficacy as part of routine oncology care.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
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