Drug interactions
Pacritinib + Quinine
Severity: Major
Pacritinib and Quinine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib may inhibit CYP3A4 and raise quinine concentrations. Higher quinine exposure increases the risk of cinchonism, hypoglycemia and QT prolongation.
What this interaction means in plain words
Pacritinib and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pacritinib belongs to Oncology; Quinine belongs to Anti Parasitic.
Why it happens
Pacritinib inhibits CYP3A4, reducing the metabolic clearance of quinine.
What to do
Avoid the combination if an alternative antimalarial is available. If used, monitor ECG and blood glucose and watch for signs of quinine toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Pacritinib with Quinine?
MediHelp rates the interaction as major. Pacritinib and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pacritinib may inhibit CYP3A4 and raise quinine concentrations. Higher quinine exposure increases the risk of cinchonism, hypoglycemia and QT prolongation.
How serious is the interaction between Pacritinib and Quinine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative antimalarial is available. If used, monitor ECG and blood glucose and watch for signs of quinine toxicity.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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