Drug interactions
Pacritinib + Siponimod
Severity: Moderate
Pacritinib and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib is a JAK2/FLT3 inhibitor that can cause cytopenias and infections, and siponimod lowers lymphocytes. Pacritinib also prolongs QT and can cause bradycardia, which may compound siponimod's cardiac effects.
What this interaction means in plain words
Pacritinib and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pacritinib belongs to Oncology; Siponimod belongs to Central Nervous System.
Why it happens
Additive immunosuppression and overlapping cardiac effects (QT prolongation and bradycardia).
What to do
Monitor infection signs, blood counts and ECG, particularly at siponimod initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Pacritinib with Siponimod?
MediHelp rates the interaction as moderate. Pacritinib and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pacritinib is a JAK2/FLT3 inhibitor that can cause cytopenias and infections, and siponimod lowers lymphocytes. Pacritinib also prolongs QT and can cause bradycardia, which may compound siponimod's cardiac effects.
How serious is the interaction between Pacritinib and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor infection signs, blood counts and ECG, particularly at siponimod initiation.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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