Drug interactions
Palbociclib + Sertraline
Severity: Minor
Palbociclib and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is metabolized by CYP3A4, and sertraline is only a weak inhibitor of this enzyme. Any increase in palbociclib exposure is likely small.
What this interaction means in plain words
Palbociclib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Palbociclib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline.
What to do
No dose change is generally needed. Monitor blood counts as routinely done for palbociclib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Palbociclib with Sertraline?
MediHelp rates the interaction as minor. Palbociclib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Palbociclib is metabolized by CYP3A4, and sertraline is only a weak inhibitor of this enzyme. Any increase in palbociclib exposure is likely small.
How serious is the interaction between Palbociclib and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor blood counts as routinely done for palbociclib.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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