Drug interactions
Palbociclib + Ticagrelor
Severity: Minor
Palbociclib and Ticagrelor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticagrelor is a weak CYP3A4 inhibitor and may slightly increase palbociclib exposure. The effect is likely small, but neutropenia could be more likely.
What this interaction means in plain words
Palbociclib and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Palbociclib belongs to Oncology; Ticagrelor belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by ticagrelor reduces palbociclib metabolism.
What to do
No dose change is usually needed; monitor blood counts as routine for palbociclib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Palbociclib
Frequently asked questions
Can I take Palbociclib with Ticagrelor?
MediHelp rates the interaction as minor. Palbociclib and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ticagrelor is a weak CYP3A4 inhibitor and may slightly increase palbociclib exposure. The effect is likely small, but neutropenia could be more likely.
How serious is the interaction between Palbociclib and Ticagrelor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor blood counts as routine for palbociclib.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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