Drug interactions
Palbociclib + Verapamil
Severity: Moderate
Palbociclib and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may increase palbociclib exposure, raising the risk of neutropenia and other adverse effects. The effect is expected to be moderate.
What this interaction means in plain words
Palbociclib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palbociclib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4, reducing palbociclib clearance.
What to do
Monitor neutrimmune counts regularly and reduce the palbociclib dose if neutropenia or toxicity occurs. Consider a non-inhibiting alternative where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Palbociclib
Frequently asked questions
Can I take Palbociclib with Verapamil?
MediHelp rates the interaction as moderate. Palbociclib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil may increase palbociclib exposure, raising the risk of neutropenia and other adverse effects. The effect is expected to be moderate.
How serious is the interaction between Palbociclib and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrimmune counts regularly and reduce the palbociclib dose if neutropenia or toxicity occurs. Consider a non-inhibiting alternative where possible.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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