Drug interactions
Palbociclib + Voxelotor
Severity: Moderate
Palbociclib and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor increases exposure to sensitive CYP3A4 substrates and may raise palbociclib levels. This could increase palbociclib toxicity, particularly neutropenia.
What this interaction means in plain words
Palbociclib and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palbociclib belongs to Oncology; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, decreasing palbociclib clearance.
What to do
Monitor complete blood counts and consider reducing the palbociclib dose if toxicity appears. Use an alternative if it can be arranged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palbociclib
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Palbociclib with Voxelotor?
MediHelp rates the interaction as moderate. Palbociclib and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor increases exposure to sensitive CYP3A4 substrates and may raise palbociclib levels. This could increase palbociclib toxicity, particularly neutropenia.
How serious is the interaction between Palbociclib and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and consider reducing the palbociclib dose if toxicity appears. Use an alternative if it can be arranged.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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