Drug interactions
Paliperidone + Papaverine
Severity: Minor
Paliperidone and Papaverine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaverine can cause sedation and hypotension, which may add to the drowsiness and orthostatic effects of paliperidone. The clinical effect is generally small.
What this interaction means in plain words
Paliperidone and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paliperidone belongs to Central Nervous System; Papaverine belongs to Cardiovascular.
Why it happens
Additive CNS depressant and vasodilatory effects.
What to do
Monitor for drowsiness and orthostatic hypotension, particularly in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Paliperidone with Papaverine?
MediHelp rates the interaction as minor. Paliperidone and Papaverine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Papaverine can cause sedation and hypotension, which may add to the drowsiness and orthostatic effects of paliperidone. The clinical effect is generally small.
How serious is the interaction between Paliperidone and Papaverine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and orthostatic hypotension, particularly in older patients.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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