Drug interactions
Paliperidone + Pomalidomide
Severity: Minor
Paliperidone and Pomalidomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pomalidomide is a P-glycoprotein substrate and paliperidone is a weak P-gp inhibitor in vitro, so pomalidomide exposure could theoretically rise. A meaningful clinical effect is unlikely.
What this interaction means in plain words
Paliperidone and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paliperidone belongs to Central Nervous System; Pomalidomide belongs to Miscellaneous.
Why it happens
Possible weak P-glycoprotein inhibition by paliperidone reducing pomalidomide efflux.
What to do
No dose adjustment is routinely required. Monitor for pomalidomide adverse effects such as neutropenia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Pomalidomide
- Deferiprone + Pomalidomide Major
- Ethinyl estradiol-drospirenone + Pomalidomide Major
- Fluvoxamine + Pomalidomide Major
- Apalutamide + Pomalidomide Moderate
- Brivaracetam + Pomalidomide Moderate
- Carbamazepine + Pomalidomide Moderate
Frequently asked questions
Can I take Paliperidone with Pomalidomide?
MediHelp rates the interaction as minor. Paliperidone and Pomalidomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pomalidomide is a P-glycoprotein substrate and paliperidone is a weak P-gp inhibitor in vitro, so pomalidomide exposure could theoretically rise. A meaningful clinical effect is unlikely.
How serious is the interaction between Paliperidone and Pomalidomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely required. Monitor for pomalidomide adverse effects such as neutropenia.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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