Drug interactions
Paliperidone + Rilpivirine
Severity: Moderate
Paliperidone and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine at supratherapeutic doses prolongs the QT interval, and paliperidone also carries a QT-prolonging effect. Combining them may increase the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Paliperidone and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paliperidone belongs to Central Nervous System; Rilpivirine belongs to Anti Virals.
Why it happens
Additive QTc prolongation.
What to do
Obtain an ECG at baseline and during therapy in patients with cardiac risk factors, and correct potassium and magnesium abnormalities. Consider alternatives if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Paliperidone with Rilpivirine?
MediHelp rates the interaction as moderate. Paliperidone and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilpivirine at supratherapeutic doses prolongs the QT interval, and paliperidone also carries a QT-prolonging effect. Combining them may increase the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Paliperidone and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at baseline and during therapy in patients with cardiac risk factors, and correct potassium and magnesium abnormalities. Consider alternatives if the QTc becomes markedly prolonged.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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