Drug interactions
Paliperidone + Sirolimus
Severity: Minor
Paliperidone and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus may inhibit P-glycoprotein and modestly raise paliperidone concentrations. The clinical impact is probably small but may increase adverse effects such as sedation or QT effects.
What this interaction means in plain words
Paliperidone and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paliperidone belongs to Central Nervous System; Sirolimus belongs to Miscellaneous.
Why it happens
Possible inhibition of P-glycoprotein efflux of paliperidone.
What to do
Monitor for increased paliperidone adverse effects such as sedation, extrapyramidal symptoms and hypotension; reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Paliperidone with Sirolimus?
MediHelp rates the interaction as minor. Paliperidone and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sirolimus may inhibit P-glycoprotein and modestly raise paliperidone concentrations. The clinical impact is probably small but may increase adverse effects such as sedation or QT effects.
How serious is the interaction between Paliperidone and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased paliperidone adverse effects such as sedation, extrapyramidal symptoms and hypotension; reduce the dose if they occur.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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