Drug interactions
Paliperidone + Solifenacin
Severity: Moderate
Paliperidone and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone can prolong the QT interval and solifenacin may add to this effect. Risk is higher in patients with bradycardia, electrolyte disturbance or renal impairment that raises paliperidone levels.
What this interaction means in plain words
Paliperidone and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paliperidone belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain an ECG and electrolytes at baseline in patients with cardiac risk factors. Monitor the QTc and adjust therapy if it becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Paliperidone with Solifenacin?
MediHelp rates the interaction as moderate. Paliperidone and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone can prolong the QT interval and solifenacin may add to this effect. Risk is higher in patients with bradycardia, electrolyte disturbance or renal impairment that raises paliperidone levels.
How serious is the interaction between Paliperidone and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG and electrolytes at baseline in patients with cardiac risk factors. Monitor the QTc and adjust therapy if it becomes prolonged.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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