Drug interactions
Palovarotene + Posaconazole
Severity: Major
Palovarotene and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palovarotene is a CYP3A4 substrate, so a strong inhibitor like posaconazole can raise retinoid exposure. This may increase retinoid toxicity such as mucocutaneous effects, premature epiphyseal closure in children and hypervitaminosis A-type effects.
What this interaction means in plain words
Palovarotene and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Palovarotene belongs to Miscellaneous; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of palovarotene, increasing its systemic exposure.
What to do
Avoid concomitant use where possible and choose an antifungal with less CYP3A4 inhibition. If it cannot be avoided, monitor closely for retinoid toxicity and follow the palovarotene labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Palovarotene
- Acitretin + Palovarotene Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Amiodarone + Palovarotene Major
- Amobarbital + Palovarotene Major
- Apalutamide + Palovarotene Major
- Aprepitant + Palovarotene Major
Frequently asked questions
Can I take Palovarotene with Posaconazole?
MediHelp rates the interaction as major. Palovarotene and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palovarotene is a CYP3A4 substrate, so a strong inhibitor like posaconazole can raise retinoid exposure. This may increase retinoid toxicity such as mucocutaneous effects, premature epiphyseal closure in children and hypervitaminosis A-type effects.
How serious is the interaction between Palovarotene and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible and choose an antifungal with less CYP3A4 inhibition. If it cannot be avoided, monitor closely for retinoid toxicity and follow the palovarotene labeling.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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