Drug interactions
Pancuronium + Paromomycin
Severity: Moderate
Pancuronium and Paromomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin is minimally absorbed, but absorption can rise with inflamed bowel or renal impairment. Systemic exposure may potentiate pancuronium and prolong paralysis.
What this interaction means in plain words
Pancuronium and Paromomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pancuronium belongs to Musculoskeletal; Paromomycin belongs to Anti Bacterial.
Why it happens
Absorbed aminoglycoside impairs acetylcholine release and postsynaptic sensitivity, adding to nondepolarizing blockade.
What to do
Monitor with train-of-four and keep ventilatory support available. Reduce pancuronium dose as needed in bowel disease or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pancuronium
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Pancuronium with Paromomycin?
MediHelp rates the interaction as moderate. Pancuronium and Paromomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral paromomycin is minimally absorbed, but absorption can rise with inflamed bowel or renal impairment. Systemic exposure may potentiate pancuronium and prolong paralysis.
How serious is the interaction between Pancuronium and Paromomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor with train-of-four and keep ventilatory support available. Reduce pancuronium dose as needed in bowel disease or renal impairment.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
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