Drug interactions
Panobinostat + Quetiapine
Severity: Major
Panobinostat and Quetiapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat prolongs the QT interval and quetiapine has additional QT effects, so combining them increases the risk of torsades de pointes. Labeling advises against panobinostat with QT-prolonging drugs.
What this interaction means in plain words
Panobinostat and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Panobinostat belongs to Oncology; Quetiapine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Avoid the combination and use a non-QT-prolonging antipsychotic if one is needed. If unavoidable, monitor ECG and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Panobinostat with Quetiapine?
MediHelp rates the interaction as major. Panobinostat and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Panobinostat prolongs the QT interval and quetiapine has additional QT effects, so combining them increases the risk of torsades de pointes. Labeling advises against panobinostat with QT-prolonging drugs.
How serious is the interaction between Panobinostat and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-QT-prolonging antipsychotic if one is needed. If unavoidable, monitor ECG and keep potassium and magnesium within normal range.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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