Drug interactions
Panobinostat + Ziprasidone
Severity: Contraindicated
Panobinostat and Ziprasidone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat prolongs the QT interval and ziprasidone has the same effect. Together they raise the risk of torsades de pointes, and panobinostat labeling advises against using it with QT-prolonging drugs.
What this interaction means in plain words
Panobinostat and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Panobinostat belongs to Oncology; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive delayed cardiac repolarization through hERG channel inhibition and altered ion channel function.
What to do
Do not combine them; choose an antipsychotic with a lower QT liability. If panobinostat therapy is essential, review the psychiatric regimen with the prescriber before starting it.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Panobinostat with Ziprasidone?
MediHelp rates the interaction as contraindicated. Panobinostat and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Panobinostat prolongs the QT interval and ziprasidone has the same effect. Together they raise the risk of torsades de pointes, and panobinostat labeling advises against using it with QT-prolonging drugs.
How serious is the interaction between Panobinostat and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine them; choose an antipsychotic with a lower QT liability. If panobinostat therapy is essential, review the psychiatric regimen with the prescriber before starting it.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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