Drug interactions
Pantoprazole + Posaconazole
Severity: Moderate
Pantoprazole and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole oral suspension depends on gastric acidity for absorption, and proton pump inhibitors can lower its exposure. The delayed-release tablet is much less affected, so the effect depends on the formulation.
What this interaction means in plain words
Pantoprazole and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pantoprazole belongs to Gastrointestinal Tract; Posaconazole belongs to Anti Fungals.
Why it happens
Raised gastric pH reduces dissolution and absorption of posaconazole suspension.
What to do
Use the delayed-release tablet or intravenous posaconazole when acid suppression is needed, or avoid PPIs with the suspension. Monitor posaconazole trough levels if the suspension must be used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Pantoprazole with Posaconazole?
MediHelp rates the interaction as moderate. Pantoprazole and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole oral suspension depends on gastric acidity for absorption, and proton pump inhibitors can lower its exposure. The delayed-release tablet is much less affected, so the effect depends on the formulation.
How serious is the interaction between Pantoprazole and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the delayed-release tablet or intravenous posaconazole when acid suppression is needed, or avoid PPIs with the suspension. Monitor posaconazole trough levels if the suspension must be used.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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