Drug interactions
Pantoprazole + Talazoparib
Severity: Moderate
Pantoprazole and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talazoparib is a BCRP substrate and pantoprazole can inhibit BCRP, so talazoparib exposure may rise. This could increase hematologic toxicity, though the clinical effect is not well characterized.
What this interaction means in plain words
Pantoprazole and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pantoprazole belongs to Gastrointestinal Tract; Talazoparib belongs to Oncology.
Why it happens
Pantoprazole may inhibit intestinal BCRP efflux, raising talazoparib absorption.
What to do
Monitor blood counts regularly and reduce talazoparib dose per labeling if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Pantoprazole with Talazoparib?
MediHelp rates the interaction as moderate. Pantoprazole and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talazoparib is a BCRP substrate and pantoprazole can inhibit BCRP, so talazoparib exposure may rise. This could increase hematologic toxicity, though the clinical effect is not well characterized.
How serious is the interaction between Pantoprazole and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts regularly and reduce talazoparib dose per labeling if toxicity develops.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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