Drug interactions
Papaverine + Pentazocine
Severity: Minor
Papaverine and Pentazocine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaverine has only mild sedative properties, and clinically important additive sedation with pentazocine is not well documented. Any effect is likely small, though some drowsiness or lowered blood pressure is conceivable.
What this interaction means in plain words
Papaverine and Pentazocine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Papaverine belongs to Cardiovascular; Pentazocine belongs to Musculoskeletal.
Why it happens
Possible weak additive CNS and vasodilatory effects; no well-established mechanism.
What to do
No specific action needed beyond awareness; monitor for excess drowsiness or hypotension if used together.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Papaverine with Pentazocine?
MediHelp rates the interaction as minor. Papaverine and Pentazocine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Papaverine has only mild sedative properties, and clinically important additive sedation with pentazocine is not well documented. Any effect is likely small, though some drowsiness or lowered blood pressure is conceivable.
How serious is the interaction between Papaverine and Pentazocine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action needed beyond awareness; monitor for excess drowsiness or hypotension if used together.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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