Drug interactions
Papaverine + Perphenazine
Severity: Minor
Papaverine and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is sedating, and papaverine may cause drowsiness or dizziness in some patients. Together they may modestly increase sedation or hypotension, though the effect is generally small.
What this interaction means in plain words
Papaverine and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Papaverine belongs to Cardiovascular; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and vasodilatory effects.
What to do
Counsel patients about drowsiness and dizziness, particularly when starting therapy. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Frequently asked questions
Can I take Papaverine with Perphenazine?
MediHelp rates the interaction as minor. Papaverine and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Perphenazine is sedating, and papaverine may cause drowsiness or dizziness in some patients. Together they may modestly increase sedation or hypotension, though the effect is generally small.
How serious is the interaction between Papaverine and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and dizziness, particularly when starting therapy. No dose change is usually needed.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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