Drug interactions
Papaverine + Ziconotide
Severity: Minor
Papaverine and Ziconotide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide, given intrathecally, can cause dizziness, confusion and reduced consciousness. Papaverine may add slightly to CNS depression, though the contribution is thought to be small.
What this interaction means in plain words
Papaverine and Ziconotide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Papaverine belongs to Cardiovascular; Ziconotide belongs to Central Nervous System.
Why it happens
Possible additive CNS depression; papaverine's contribution is weak and not well characterized.
What to do
Monitor cognitive status and level of consciousness, and reduce or stop ziconotide if significant impairment develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Papaverine with Ziconotide?
MediHelp rates the interaction as minor. Papaverine and Ziconotide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ziconotide, given intrathecally, can cause dizziness, confusion and reduced consciousness. Papaverine may add slightly to CNS depression, though the contribution is thought to be small.
How serious is the interaction between Papaverine and Ziconotide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognitive status and level of consciousness, and reduce or stop ziconotide if significant impairment develops.
What other medicines interact with Papaverine?
MediHelp also lists interactions of Papaverine with, for example, Givinostat, Bretylium, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Papaverine page.
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