Drug interactions
Paromomycin + Sulindac
Severity: Minor
Paromomycin and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral paromomycin is minimally absorbed, so systemic exposure is generally negligible. The reported NSAID effect on aminoglycoside clearance arises mainly in preterm infants and is of little relevance here.
What this interaction means in plain words
Paromomycin and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paromomycin belongs to Anti Bacterial; Sulindac belongs to Musculoskeletal.
Why it happens
NSAID-related reduction in renal clearance of aminoglycosides, relevant only with significant absorption.
What to do
No specific action is needed; monitor renal function if the patient has renal impairment or severe bowel disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Paromomycin with Sulindac?
MediHelp rates the interaction as minor. Paromomycin and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral paromomycin is minimally absorbed, so systemic exposure is generally negligible. The reported NSAID effect on aminoglycoside clearance arises mainly in preterm infants and is of little relevance here.
How serious is the interaction between Paromomycin and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed; monitor renal function if the patient has renal impairment or severe bowel disease.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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