Drug interactions
Paromomycin + Vancomycin
Severity: Minor
Paromomycin and Vancomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paromomycin is an aminoglycoside that is poorly absorbed orally, so systemic toxicity is unlikely unless absorption is increased by damaged gut mucosa or renal impairment. In such settings, combined use with vancomycin could add to nephrotoxicity and ototoxicity.
What this interaction means in plain words
Paromomycin and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paromomycin belongs to Anti Bacterial; Vancomycin belongs to Anti Bacterial.
Why it happens
Theoretical additive nephrotoxicity and ototoxicity if paromomycin is systemically absorbed.
What to do
Monitor renal function and hearing in patients with renal impairment or severe intestinal inflammation receiving both.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vancomycin
- Amikacin + Vancomycin Major
- Bacitracin + Vancomycin Major
- Capreomycin + Vancomycin Major
- Cephaloridine + Vancomycin Major
- Cidofovir + Vancomycin Major
- Cisplatin + Vancomycin Major
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Paromomycin with Vancomycin?
MediHelp rates the interaction as minor. Paromomycin and Vancomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paromomycin is an aminoglycoside that is poorly absorbed orally, so systemic toxicity is unlikely unless absorption is increased by damaged gut mucosa or renal impairment. In such settings, combined use with vancomycin could add to nephrotoxicity and ototoxicity.
How serious is the interaction between Paromomycin and Vancomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and hearing in patients with renal impairment or severe intestinal inflammation receiving both.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
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