Drug interactions
Paromomycin + Vecuronium
Severity: Moderate
Paromomycin and Vecuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paromomycin is an oral aminoglycoside with minimal absorption, but absorption can increase with inflamed bowel or renal impairment. Systemic exposure may then potentiate vecuronium and prolong paralysis, with a risk of respiratory depression or apnea.
What this interaction means in plain words
Paromomycin and Vecuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paromomycin belongs to Anti Bacterial; Vecuronium belongs to Musculoskeletal.
Why it happens
Absorbed aminoglycoside impairs acetylcholine release and postsynaptic sensitivity, adding to nondepolarizing blockade.
What to do
Monitor neuromuscular function with train-of-four and keep ventilatory support available until full recovery. Reduce vecuronium doses as needed in patients with bowel disease or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vecuronium
Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Paromomycin with Vecuronium?
MediHelp rates the interaction as moderate. Paromomycin and Vecuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paromomycin is an oral aminoglycoside with minimal absorption, but absorption can increase with inflamed bowel or renal impairment. Systemic exposure may then potentiate vecuronium and prolong paralysis, with a risk of respiratory depression or apnea.
How serious is the interaction between Paromomycin and Vecuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and keep ventilatory support available until full recovery. Reduce vecuronium doses as needed in patients with bowel disease or renal impairment.
What other medicines interact with Vecuronium?
MediHelp also lists interactions of Vecuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Vecuronium page.
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