Drug interactions
Pazopanib + Sodium zirconium cyclosilicate
Severity: Moderate
Pazopanib and Sodium zirconium cyclosilicate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib solubility decreases as pH rises, and sodium zirconium cyclosilicate may increase gastric pH. This may lower pazopanib absorption and efficacy.
What this interaction means in plain words
Pazopanib and Sodium zirconium cyclosilicate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pazopanib belongs to Oncology; Sodium zirconium cyclosilicate belongs to Miscellaneous.
Why it happens
Increased gastric pH reduces pazopanib solubility and absorption.
What to do
Administer pazopanib at least 2 hours before or after sodium zirconium cyclosilicate. Monitor tumor response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Cefuroxime + Sodium zirconium cyclosilicate Moderate
- Crizotinib + Sodium zirconium cyclosilicate Moderate
- Dasatinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Pazopanib with Sodium zirconium cyclosilicate?
MediHelp rates the interaction as moderate. Pazopanib and Sodium zirconium cyclosilicate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib solubility decreases as pH rises, and sodium zirconium cyclosilicate may increase gastric pH. This may lower pazopanib absorption and efficacy.
How serious is the interaction between Pazopanib and Sodium zirconium cyclosilicate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Administer pazopanib at least 2 hours before or after sodium zirconium cyclosilicate. Monitor tumor response.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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