Drug interactions
Pazopanib + Tepotinib
Severity: Moderate
Pazopanib and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-gp and may increase exposure to P-gp substrates like pazopanib. Higher levels could increase hepatotoxicity and hypertension.
What this interaction means in plain words
Pazopanib and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pazopanib belongs to Oncology; Tepotinib belongs to Oncology.
Why it happens
Tepotinib inhibits intestinal and cellular P-gp efflux, increasing pazopanib absorption and exposure.
What to do
Monitor liver function tests and blood pressure closely. Consider reducing pazopanib if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Pazopanib with Tepotinib?
MediHelp rates the interaction as moderate. Pazopanib and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-gp and may increase exposure to P-gp substrates like pazopanib. Higher levels could increase hepatotoxicity and hypertension.
How serious is the interaction between Pazopanib and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and blood pressure closely. Consider reducing pazopanib if toxicity develops.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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