Drug interactions
Pazopanib + Teriflunomide
Severity: Moderate
Pazopanib and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is mainly metabolized by CYP3A4 with minor CYP2C8 involvement, so teriflunomide may modestly raise exposure. Both drugs can cause liver injury, so combined hepatotoxicity is of concern.
What this interaction means in plain words
Pazopanib and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pazopanib belongs to Oncology; Teriflunomide belongs to Central Nervous System.
Why it happens
CYP2C8 inhibition by teriflunomide may reduce pazopanib clearance, with additive hepatotoxicity.
What to do
Monitor liver enzymes closely and reduce or interrupt pazopanib if transaminases rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Teriflunomide
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Teriflunomide?
MediHelp rates the interaction as moderate. Pazopanib and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib is mainly metabolized by CYP3A4 with minor CYP2C8 involvement, so teriflunomide may modestly raise exposure. Both drugs can cause liver injury, so combined hepatotoxicity is of concern.
How serious is the interaction between Pazopanib and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely and reduce or interrupt pazopanib if transaminases rise.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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