Drug interactions
Pefloxacin + Riluzole
Severity: Moderate
Pefloxacin and Riluzole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Riluzole is metabolized mainly by CYP1A2, and pefloxacin, like several quinolones, may inhibit this enzyme. Riluzole exposure may rise, increasing the risk of adverse effects such as nausea, dizziness and liver enzyme elevation.
What this interaction means in plain words
Pefloxacin and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pefloxacin belongs to Anti Bacterial; Riluzole belongs to Miscellaneous.
Why it happens
Inhibition of CYP1A2-mediated riluzole metabolism by pefloxacin.
What to do
Monitor liver function tests and for riluzole adverse effects when the combination is used. Consider an alternative antibiotic if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Riluzole
- Fluvoxamine + Riluzole Major
- Cannabidiol + Riluzole Moderate
- Ciprofloxacin + Riluzole Moderate
- Elranatamab + Riluzole Moderate
- Epcoritamab + Riluzole Moderate
- Fexinidazole + Riluzole Moderate
Other interactions of Pefloxacin
- Pefloxacin + Tizanidine Contraindicated
- Clozapine + Pefloxacin Major
- Duloxetine + Pefloxacin Major
- Pefloxacin + Theophylline Major
- Asenapine + Pefloxacin Moderate
- Caffeine + Pefloxacin Moderate
Frequently asked questions
Can I take Pefloxacin with Riluzole?
MediHelp rates the interaction as moderate. Pefloxacin and Riluzole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Riluzole is metabolized mainly by CYP1A2, and pefloxacin, like several quinolones, may inhibit this enzyme. Riluzole exposure may rise, increasing the risk of adverse effects such as nausea, dizziness and liver enzyme elevation.
How serious is the interaction between Pefloxacin and Riluzole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and for riluzole adverse effects when the combination is used. Consider an alternative antibiotic if adverse effects develop.
What other medicines interact with Riluzole?
MediHelp also lists interactions of Riluzole with, for example, Fluvoxamine, Cannabidiol, Ciprofloxacin. The full list is on the Riluzole page.
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