Drug interactions
Pegaspargase + Piroxicam
Severity: Moderate
Pegaspargase and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegaspargase can cause coagulation abnormalities and thrombocytopenia, and NSAIDs impair platelet function, so bleeding risk may increase.
What this interaction means in plain words
Pegaspargase and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pegaspargase belongs to Oncology; Piroxicam belongs to Musculoskeletal.
Why it happens
Asparaginase-related reductions in clotting factors add to NSAID antiplatelet effects.
What to do
Avoid NSAIDs where possible during pegaspargase therapy. Monitor platelets and coagulation parameters if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Pegaspargase
- Etodolac + Pegaspargase Major
- Ketorolac + Pegaspargase Major
- Mefenamic acid + Pegaspargase Major
- Acetylsalicylic acid + Pegaspargase Moderate
- Argatroban + Pegaspargase Moderate
- Celecoxib + Pegaspargase Moderate
Frequently asked questions
Can I take Pegaspargase with Piroxicam?
MediHelp rates the interaction as moderate. Pegaspargase and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegaspargase can cause coagulation abnormalities and thrombocytopenia, and NSAIDs impair platelet function, so bleeding risk may increase.
How serious is the interaction between Pegaspargase and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible during pegaspargase therapy. Monitor platelets and coagulation parameters if used.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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