Drug interactions
Peginterferon alfa 2b + Voriconazole
Severity: Minor
Peginterferon alfa 2b and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa-2b can down-regulate hepatic CYP activity, which may in theory increase exposure to CYP substrates such as voriconazole. The clinical effect is not well characterized and the direction of change is uncertain.
What this interaction means in plain words
Peginterferon alfa 2b and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Peginterferon alfa 2b belongs to Anti Virals; Voriconazole belongs to Anti Fungals.
Why it happens
Interferon-mediated suppression of hepatic CYP enzymes; the effect on voriconazole is not firmly established.
What to do
Monitor voriconazole trough concentrations and clinical response or toxicity if both are used together, adjusting the dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Peginterferon alfa 2b
Frequently asked questions
Can I take Peginterferon alfa 2b with Voriconazole?
MediHelp rates the interaction as minor. Peginterferon alfa 2b and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peginterferon alfa-2b can down-regulate hepatic CYP activity, which may in theory increase exposure to CYP substrates such as voriconazole. The clinical effect is not well characterized and the direction of change is uncertain.
How serious is the interaction between Peginterferon alfa 2b and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor voriconazole trough concentrations and clinical response or toxicity if both are used together, adjusting the dose as needed.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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