Drug interactions
Pegvisomant + Tolazamide
Severity: Moderate
Pegvisomant and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvisomant blocks growth hormone action and improves insulin sensitivity in acromegaly, and cases of hypoglycemia have occurred in patients on antidiabetic drugs. A sulfonylurea may therefore need a dose reduction.
What this interaction means in plain words
Pegvisomant and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pegvisomant belongs to Endocrine; Tolazamide belongs to Endocrine.
Why it happens
Growth hormone receptor antagonism reduces insulin resistance, adding to the glucose-lowering effect of tolazamide.
What to do
Monitor blood glucose when pegvisomant is started or the dose is raised. Reduce the tolazamide dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Pegvisomant with Tolazamide?
MediHelp rates the interaction as moderate. Pegvisomant and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegvisomant blocks growth hormone action and improves insulin sensitivity in acromegaly, and cases of hypoglycemia have occurred in patients on antidiabetic drugs. A sulfonylurea may therefore need a dose reduction.
How serious is the interaction between Pegvisomant and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when pegvisomant is started or the dose is raised. Reduce the tolazamide dose if glucose falls.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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