Drug interactions
Penicillin g + Probenecid
Severity: Moderate
Penicillin g and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid blocks renal tubular secretion of penicillin G, raising and prolonging its plasma concentrations. This is sometimes used deliberately to boost penicillin levels, for example in neurosyphilis regimens, but can increase the risk of dose-related adverse effects.
What this interaction means in plain words
Penicillin g and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Penicillin g belongs to Anti Bacterial; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits organic anion transporters (OAT1/OAT3) in the proximal tubule, reducing penicillin renal clearance.
What to do
If the combination is intentional, use established regimens; otherwise monitor for penicillin toxicity such as seizures and adjust dose in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Penicillin g
- Amifampridine + Penicillin g Moderate
- Amiloride + Penicillin g Moderate
- Bcg vaccine live + Penicillin g Moderate
- Cholera vaccine + Penicillin g Moderate
- Colestipol + Penicillin g Moderate
- Deflazacort + Penicillin g Moderate
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Penicillin g with Probenecid?
MediHelp rates the interaction as moderate. Penicillin g and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid blocks renal tubular secretion of penicillin G, raising and prolonging its plasma concentrations. This is sometimes used deliberately to boost penicillin levels, for example in neurosyphilis regimens, but can increase the risk of dose-related adverse effects.
How serious is the interaction between Penicillin g and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If the combination is intentional, use established regimens; otherwise monitor for penicillin toxicity such as seizures and adjust dose in renal impairment.
What other medicines interact with Penicillin g?
MediHelp also lists interactions of Penicillin g with, for example, Amifampridine, Amiloride, Bcg vaccine live. The full list is on the Penicillin g page.
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