Drug interactions
Pentamidine + Valganciclovir
Severity: Moderate
Pentamidine and Valganciclovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine can cause nephrotoxicity, leukopenia and thrombocytopenia, and ganciclovir causes myelosuppression. Together they may increase hematologic toxicity, and renal injury could further reduce ganciclovir clearance.
What this interaction means in plain words
Pentamidine and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pentamidine belongs to Anti Parasitic; Valganciclovir belongs to Anti Virals.
Why it happens
Additive myelosuppression and nephrotoxicity.
What to do
Monitor complete blood counts and serum creatinine regularly. Adjust valganciclovir to renal function and reduce or stop a drug if cytopenias or renal injury develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valganciclovir
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
Frequently asked questions
Can I take Pentamidine with Valganciclovir?
MediHelp rates the interaction as moderate. Pentamidine and Valganciclovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentamidine can cause nephrotoxicity, leukopenia and thrombocytopenia, and ganciclovir causes myelosuppression. Together they may increase hematologic toxicity, and renal injury could further reduce ganciclovir clearance.
How serious is the interaction between Pentamidine and Valganciclovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and serum creatinine regularly. Adjust valganciclovir to renal function and reduce or stop a drug if cytopenias or renal injury develop.
What other medicines interact with Valganciclovir?
MediHelp also lists interactions of Valganciclovir with, for example, Didanosine, Ganciclovir, Liposomal doxorubicin. The full list is on the Valganciclovir page.
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