Drug interactions
Pentazocine + Perphenazine
Severity: Moderate
Pentazocine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined use can increase sedation, dizziness and hypotension. Phenothiazines may also potentiate opioid-induced respiratory depression.
What this interaction means in plain words
Pentazocine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pentazocine belongs to Musculoskeletal; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension from opioid activity and phenothiazine receptor blockade.
What to do
Start with reduced doses of either drug and monitor sedation, respiratory rate and blood pressure. Counsel against alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Pentazocine with Perphenazine?
MediHelp rates the interaction as moderate. Pentazocine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined use can increase sedation, dizziness and hypotension. Phenothiazines may also potentiate opioid-induced respiratory depression.
How serious is the interaction between Pentazocine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced doses of either drug and monitor sedation, respiratory rate and blood pressure. Counsel against alcohol and driving.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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