Drug interactions
Pentobarbital + Silodosin
Severity: Moderate
Pentobarbital and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces CYP3A4 and may lower silodosin concentrations. This could reduce the effect on urinary symptoms. It is not expected to be dangerous.
What this interaction means in plain words
Pentobarbital and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of CYP3A4 increases silodosin metabolism.
What to do
Monitor for loss of urinary symptom control and adjust therapy if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Pentobarbital with Silodosin?
MediHelp rates the interaction as moderate. Pentobarbital and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital induces CYP3A4 and may lower silodosin concentrations. This could reduce the effect on urinary symptoms. It is not expected to be dangerous.
How serious is the interaction between Pentobarbital and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of urinary symptom control and adjust therapy if efficacy declines.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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