Drug interactions
Pentoxifylline + Warfarin
Severity: Moderate
Pentoxifylline and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentoxifylline has hemorheologic and mild antiplatelet effects, and bleeding and raised INR have been reported with warfarin. The combination can increase bleeding risk.
What this interaction means in plain words
Pentoxifylline and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pentoxifylline belongs to Cardiovascular; Warfarin belongs to Cardiovascular.
Why it happens
Additive antiplatelet and hemorheologic effect with vitamin K antagonism.
What to do
Monitor INR and bleeding signs when starting or stopping pentoxifylline, and adjust warfarin dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Pentoxifylline
- Amifostine + Pentoxifylline Moderate
- Fluoxetine + Pentoxifylline Moderate
- Fluvoxamine + Pentoxifylline Moderate
- Insulin degludec / insulin aspart + Pentoxifylline Moderate
- Methoxsalen + Pentoxifylline Moderate
- Mexiletine + Pentoxifylline Moderate
Frequently asked questions
Can I take Pentoxifylline with Warfarin?
MediHelp rates the interaction as moderate. Pentoxifylline and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentoxifylline has hemorheologic and mild antiplatelet effects, and bleeding and raised INR have been reported with warfarin. The combination can increase bleeding risk.
How serious is the interaction between Pentoxifylline and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR and bleeding signs when starting or stopping pentoxifylline, and adjust warfarin dose accordingly.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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