Drug interactions
Perampanel + Promethazine
Severity: Moderate
Perampanel and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perampanel causes dizziness, somnolence and impaired coordination, and promethazine adds to these effects. The combination increases fall risk and impaired alertness.
What this interaction means in plain words
Perampanel and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perampanel belongs to Central Nervous System; Promethazine belongs to Respiratory.
Why it happens
Additive central nervous system depression.
What to do
Counsel on avoiding driving and hazardous tasks and monitor for excess sedation or gait disturbance, particularly during titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Perampanel
- Apalutamide + Perampanel Major
- Enzalutamide + Perampanel Major
- Alprazolam + Perampanel Moderate
- Amisulpride + Perampanel Moderate
- Amobarbital + Perampanel Moderate
- Asenapine + Perampanel Moderate
Frequently asked questions
Can I take Perampanel with Promethazine?
MediHelp rates the interaction as moderate. Perampanel and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perampanel causes dizziness, somnolence and impaired coordination, and promethazine adds to these effects. The combination increases fall risk and impaired alertness.
How serious is the interaction between Perampanel and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on avoiding driving and hazardous tasks and monitor for excess sedation or gait disturbance, particularly during titration.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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