Drug interactions
Perindopril + Silodosin
Severity: Moderate
Perindopril and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Silodosin and the ACE inhibitor perindopril both reduce blood pressure by different mechanisms. Together they may cause additive hypotension, with dizziness or fainting most likely at initiation or after dose increases.
What this interaction means in plain words
Perindopril and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perindopril belongs to Cardiovascular; Silodosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic hypotensive effects from alpha-1 adrenergic blockade and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Lower the dose of one agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Perindopril and Silodosin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Perindopril with Silodosin?
MediHelp rates the interaction as moderate. Perindopril and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Silodosin and the ACE inhibitor perindopril both reduce blood pressure by different mechanisms. Together they may cause additive hypotension, with dizziness or fainting most likely at initiation or after dose increases.
How serious is the interaction between Perindopril and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Lower the dose of one agent if symptomatic hypotension occurs.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
